Chronic Myeloid LeukaemiaIncidence of 1 per 100 000 population. Symptoms are usually chronic and non-specific, but splenomegaly is common and may extend beyond the umbilicus. Lymphadenopathy is not usually prominent. Neutrophilia is common and may be accompanied by thrombocytosis, basophilia, monocytosis, or eosinophilia.
Acute LeukaemiasAcute Lymphoblastic Leukaemia
Common at 2-10 years with a peak at 3-4 years
Secondary rise after 40 years
Acute lymphoblastic leukaemia is slightly more common among males than females
Acute Myeloid Leukaemia
10-15% of childhood leukaemia but is the commonest leukaemia of adulthood
Incidence increases with age, and the median age at presentation is 60 years.
Acute myeloid leukaemia is equally common among males and females
Bone Failure - signs of anaemia.
neutropenia - infections of the mouth, throat, skin or perianal region
thrombocytopenia - spontaneous bruising, menorrhagia, bleeding from venepuncture sites, gingival bleeding or prolonged nose bleeds
“B symptoms”- fevers, night sweats, and unexplained weight loss
- Anaemia - normocytic
- Low platelets
- Low white cell count - neutropenia with lymphocytosis
- Chest radiography is mandatory to exclude the presence of a mediastinal mass